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Anti-pseudomonal activity of collagen sponge with liposomal polymyxin B
E A Trafny1, J Grzybowski, M Olszowska-Golec
1Department of Microbiology, Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
Abstract:
An antibiotic delivery system has been developed using collagen sponge with liposome-encapsulated polymyxin B. Superficial, non-lethal infection was produced in mice by injecting Pseudomonas aeruginosa into the skin windows. Wounds were dressed with collagen sponge containing liposomal polymyxin B or containing empty liposomes (with PBS) as a control. Single dose of topically applied collagen sponge with encapsulated polymyxin B decreased bacterial cell number as compared to the control. Finally, after 8 days of experiment, the number of bacterial colonies dropped below 10(4) per biopsy. Presented polymyxin B delivery system offers potential clinical advantages.