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Regulation of IGFBP-1 in humans
K Brismar1, A Hilding, B Lindgren
1Department of Molecular Medicine, Unit for Endocrinology and Diabetology, Karolinska Institute, Stockholm, Sweden.
Progress in Growth Factor Research
|January 1, 1995
Abstract:
IGFBP-1 secretion in humans is regulated by insulin and the counter-regulatory hormones with a high production rate and rapid turnover. The IGFBP-1 fasting levels are both genetically and environmentally determined. Serum IGFBP-1 levels may be regulated by so far unknown factors during certain conditions. The fasting IGFBP-1 level can be used as a marker of diurnal IGFBP-1 and insulin secretion.