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Chemiluminescence flow-injection analysis of captopril applying a sensitized rhodamine 6G method
Z D Zhang1, W R Baeyens, X R Zhang
1Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, University of Ghent, Belgium.
Journal of Pharmaceutical and Biomedical Analysis
|June 1, 1996
Abstract:
A flow-injection analysis with chemiluminescence detection is described for the determination of captopril based on the photochemical reaction with cerium(IV) in sulphuric acid medium yielding a strong chemiluminescent signal which can be sensitized by some fluorescers. The proposed procedure has a linear application range of 1 x 10(-6) - 2 x 10(-4) M (r = 0.997) with a detection limit of 2 x 10(-7) M, an RSD of 2.8% at 1 x 10(-6) M captopril, and a sample measurement frequency of 500 h-1. The method was used for the simple and rapid determination of captopril in a pharmaceutical preparation.