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High-performance liquid chromatographic method for the determination of RGH-5002 in human, rabbit and rat plasma
1Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, Budapest, Hungary.
Journal of Pharmaceutical and Biomedical Analysis
|June 1, 1996
Abstract:
A sensitive, accurate and reproducible high performance liquid chromatography (HPLC) procedure for the analysis of RGH-5002 in biological fluids was developed. After a single step liquid-liquid extraction at pH 9 using n-hexane, RGH-5002 and internal standard were eluted from a Hypersil Si column with 5 mM ammonium acetate-methanol-acetonitrile (0.5:45:50 v/v/v) at 28 degrees C. The method could accurately detect 5 ng ml-1 of RGH-5002.
