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[Tizanidine for preanesthetic medication]

M Takenaka1, H Iida, M Kasamatsu

  • 1Department of Anesthesiology, Ibi General Hospital, Gifu.

Masui. the Japanese Journal of Anesthesiology
|August 1, 1996
PubMed
Summary

Tizanidine as preanesthetic medication significantly improved sedation and hypnosis while reducing blood pressure increases during anesthesia induction. This suggests tizanidine is beneficial for general anesthesia.

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Premedication is crucial for optimizing patient status before anesthesia.
  • Tizanidine, an alpha-2 adrenergic agonist, has demonstrated sedative and analgesic properties.

Purpose of the Study:

  • To evaluate the effects of tizanidine premedication on perioperative hemodynamics, sedation, hypnosis, and anesthetic induction requirements.

Main Methods:

  • A randomized controlled trial involving 68 patients undergoing elective surgery under general anesthesia.
  • Patients were divided into three groups: tizanidine 4 mg, tizanidine 2 mg, or no premedication.
  • Hemodynamic parameters, sedation, hypnosis, and midazolam requirements were assessed.

Main Results:

  • Tizanidine 4 mg significantly attenuated the increase in mean blood pressure during anesthesia induction.

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  • Sedative and hypnotic effects were significantly enhanced in the tizanidine 4 mg group.
  • Reduced midazolam dosage was required for loss of consciousness in patients receiving tizanidine 4 mg.

    • Conclusions:

    • Tizanidine, particularly at a 4 mg dose, is effective as a preanesthetic medication.
    • It improves hemodynamic stability, sedation, and hypnosis, while reducing anesthetic induction agent requirements.