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Zieve's syndrome a potential surgical pitfall?
C R Pilcher1, R G Underwood, H R Smith
1Cambridge Military Hospital, Aldershot, Hants.
Journal of the Royal Army Medical Corps
|June 1, 1996
Summary
Zieve's syndrome is a rare condition characterized by temporary hemolytic anemia, jaundice, and high lipid levels, often linked to alcohol-induced liver disease. It can manifest acutely with abdominal pain, making early diagnosis crucial.
Area of Science:
- Hepatology
- Hematology
- Clinical Medicine
Background:
- Zieve's syndrome is a rare clinical entity characterized by a specific triad of symptoms.
- It is associated with alcohol-induced liver disease and presents with transient hemolytic anemia, jaundice, and hyperlipidemia.
- Fewer than 75 cases have been documented in medical literature since 1966, highlighting its rarity.
Observation:
- The syndrome is infrequently reported, with fewer than 75 cases documented since 1966.
- Presents acutely with abdominal pain.
- Involves a combination of hematological and hepatic abnormalities.
Findings:
- Transient hemolytic anemia.
- Jaundice.
- Hyperlipidaemia.
- Alcohol-induced liver disease.
Implications:
- Highlights the complex interplay between alcohol consumption and metabolic/hematological derangements.
- Requires prompt diagnosis for effective management of acute presentations.
- Underscores the importance of considering Zieve's syndrome in patients with alcohol use disorder presenting with abdominal pain and jaundice.