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Does an inability to eradicate normal stem cells preclude the cure of some cancers?
K M Anderson1, P Bonomi, J E Harris
1Department of Medicine, Rush Medical College, Chicago, IL 60612, USA.
Medical Hypotheses
|July 1, 1996
Abstract:
Presently, identified signal transduction pathways do not alter normal stem-cell survival. With prostate cancer as a model, the argument is advanced that an inability to eradicate normal androgen-dependent prostate stem-cells precludes successful treatment of transformed, androgen-independent and metastatic progeny. While applying this idea to cancers of non-essential organs or to endocrine cancers seems feasible, the inutility of this approach for most other malignancies appears likely, although not certain.