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Pregnancy induced hypertension and antithrombin-III
M Srivastava1, S Bali, J Pandey
1Department of Obstetrics and Gynaecology, Safdarjang Hospital, New Delhi.
Indian Journal of Pathology & Microbiology
|July 1, 1995
Summary
Pregnancy-induced hypertension (PIH) in women is linked to coagulation issues. Reduced antithrombin-III (AT-III) levels correlate with PIH severity, suggesting AT-III can indicate disease progression.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Cardiovascular System
Background:
- Pregnancy-induced hypertension (PIH) encompasses conditions like pre-eclampsia and eclampsia.
- Coagulation abnormalities are frequently observed in PIH, but their specific markers require further investigation.
Purpose of the Study:
- To determine the coagulation profile in women with PIH.
- To evaluate changes in antithrombin-III (AT-III) levels in pre-eclampsia and eclampsia.
- To assess the correlation between AT-III levels and PIH severity as a potential disease marker.
Main Methods:
- Studied 119 pregnant women with PIH in their third trimester.
- Included 25 normal pregnant women and 25 non-pregnant women as controls.
- Analyzed coagulation profiles and AT-III levels across different groups.
Main Results:
- No significant differences in coagulation profiles were found between non-pregnant and normal pregnant women.
- Evidence of consumption coagulopathy was observed in PIH patients.
- AT-III activity showed a significant, linear reduction from normal pregnancy to eclampsia.
Conclusions:
- PIH is associated with consumption coagulopathy.
- Decreased AT-III activity correlates positively with PIH.
- AT-III can serve as a valuable marker for assessing PIH severity.