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Tardive dyskinesia and pregnancy and delivery complications
M H El-DeFrawi1, G Hirsch, A Jurkowicz
1Port Said Medical College, Port Said, Egypt and Queens Children's Psychiatric Center.
Child Psychiatry and Human Development
|January 1, 1996
Summary
Pregnancy and delivery complications may increase the risk of developing tardive dyskinesia (TD) in children and adolescents undergoing neuroleptic treatment. This finding highlights potential risk factors for this movement disorder.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Pharmacology
Background:
- Tardive dyskinesia (TD) is a potential side effect of long-term neuroleptic treatment.
- Identifying risk factors for TD in pediatric populations is crucial for early intervention.
Purpose of the Study:
- To investigate the association between pregnancy and delivery complications (PDCs) and the development of TD in children and adolescents.
- To explore potential risk factors contributing to treatment-emergent TD.
Main Methods:
- A comparative study involving twelve children and adolescents diagnosed with TD.
- Comparison group consisted of 49 patients receiving neuroleptic treatment without TD.
- Multiple regression analysis was employed to assess associations.
Main Results:
- A significant association was found between the diagnosis of TD and a history of pregnancy and delivery complications (PDCs).
- PDCs emerged as a notable predictor for the development of TD in this cohort.
Conclusions:
- Pregnancy and delivery complications may represent a significant risk factor for developing tardive dyskinesia in pediatric patients on neuroleptic medication.
- Further research is warranted to elucidate the mechanisms linking PDCs to TD risk.