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Related Experiment Videos

Day-night differences in mucosal plasma proteins in common cold

L Greiff1, A Akerlund, M Andersson

  • 1Department of Otorhinolaryngology, University Hospital, Lund, Sweden.

Acta Oto-Laryngologica
|January 1, 1996
PubMed
Summary

Plasma proteins like albumin and fibrinogen accumulate on the airway surface, especially at night. Common cold significantly increases this nocturnal plasma exudate on the nasal mucosa.

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Area of Science:

  • Respiratory Medicine
  • Immunology
  • Biochemistry

Background:

  • Inflammatory airway diseases often worsen in the early morning.
  • Day-night variations in plasma exudate on the airway surface are not well understood.

Purpose of the Study:

  • To investigate diurnal differences in plasma macromolecule levels on the nasal mucosa.
  • To compare these levels in healthy individuals and those with the common cold.

Main Methods:

  • 20 subjects were intranasally inoculated with coronavirus.
  • Nasal lavages were performed at 4-hour intervals over 24 hours.
  • Levels of albumin and fibrinogen in lavage fluid were quantified.

Main Results:

  • Healthy subjects showed low but increased albumin and fibrinogen at 4:00 AM.

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  • Common cold patients exhibited significantly higher albumin and fibrinogen levels, peaking at 8:00 AM (day 3) and 4:00 AM (day 4).
  • Peak protein levels in common cold patients were 5-20 times higher than other periods.

    • Conclusions:

    • A marked diurnal variation in plasma proteins on the airway surface occurs in common cold.
    • Nocturnal accumulation of plasma proteins on the nasal mucosa is increased in common cold patients compared to healthy individuals.