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The implications for childhood leukemia of infection with adenovirus
1Department of Haematology, University of Wales College of Medicine, Cardiff, UK.
Trends in Microbiology
|February 1, 1996
Abstract:
Adenoviruses have mechanisms that allow persistence in lymphoid cells and immunoevasion. They downregulate major histocompatibility complex (MHC) class I antigen expression and may trigger an autoimmune reaction against MHC class II antigens through mimicry. Adenoviral persistence could be facilitated by human leukocyte antigens A2 and DR53, thereby allowing a preleukemic clone to escape immune surveillance and progress to leukemia.