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Hypoglycemic activity and structure-activity relationship of iridoidal glycosides
T Miura1, Y Nishiyama, M Ichimaru
1Suzuka University of Medical Science and Technology, Mie, Japan.
Biological & Pharmaceutical Bulletin
|January 1, 1996
Abstract:
Four iridoidal glycosides, deacetylasperulosidic acid methyl ester (DE), scandoside methyl ester (SC), geniposide (GE) and gardenoside (GA) isolated from Gardenia jasminoides Ellis grandiflora Makino leaves, were tested hypoglycemic activity in mice. DE lowered the blood glucose level in normal mice. However, SC, GE and GA did not affect the blood glucose level in normal mice, indicating that the absolute configuration of 6 position hydroxy based (OH) should be essential for the biological activity.