Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulating the radiation response

C N Coleman1

  • 1Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02115, USA.

Stem Cells (Dayton, Ohio)
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

This review explores strategies to enhance tumor response and protect normal tissues from ionizing radiation. Advances in tumor biology are improving radiation sensitization and protection methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surveying the Challenges to Improve Linear Accelerator-based Radiation Therapy in Africa: a Unique Collaborative Platform of All 28 African Countries Offering Such Treatment.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

Developing Innovative, Robust and Affordable Medical Linear Accelerators for Challenging Environments.

Clinical oncology (Royal College of Radiologists (Great Britain))·2019
Same author

Mobilising Expertise and Resources to Close the Radiotherapy Gap in Cancer Care.

Clinical oncology (Royal College of Radiologists (Great Britain))·2016
Same author

Public health oncology: a framework for progress in low- and middle-income countries.

Annals of oncology : official journal of the European Society for Medical Oncology·2012
Same author

Normal tissue protection for improving radiotherapy: Where are the Gaps?

Translational cancer research·2012
Same author

Advances in cellular and molecular radiation oncology.

Urologic oncology·2011
Same journal

Brent A. Reynolds, pioneer of adult neural stem cell biology.

Stem cells (Dayton, Ohio)·2026
Same journal

CircVapa promotes the abnormal differentiation of small intestinal epithelial stem cells in diabetic state.

Stem cells (Dayton, Ohio)·2026
Same journal

Transforming Growth Factor beta-2 (TGFβ2) Drives Trabecular Meshwork Progenitor Cell Differentiation Through SMAD2/3 Signalling.

Stem cells (Dayton, Ohio)·2026
Same journal

Circular RNA circEGFR overexpression attenuates chemosensitivity and enhances cancer stemness via targeting IGF2BP2/SOX2 in breast cancer cells.

Stem cells (Dayton, Ohio)·2026
Same journal

Regeneration of the mammalian brain: a relic of evolution?

Stem cells (Dayton, Ohio)·2026
Same journal

Mitochondrial transfer technologies with molecular insights into clinical applications.

Stem cells (Dayton, Ohio)·2026
See all related articles

Area of Science:

  • Radiation oncology
  • Tumor biology
  • Molecular biology

Background:

  • Ionizing radiation is a cornerstone of cancer treatment.
  • Understanding tumor and normal tissue responses to radiation is crucial for optimizing therapy.
  • Hypoxic cells are often resistant to radiation therapy.

Purpose of the Study:

  • To review current and future strategies for modulating tumor and normal tissue responses to ionizing radiation.
  • To discuss the impact of emerging biological knowledge on radiation oncology.
  • To explore novel approaches in radiation sensitization and protection.

Main Methods:

  • Literature review of current and emerging research in radiation oncology.
  • Analysis of clinical results with hypoxic cell sensitizers.

Related Experiment Videos

  • Discussion of novel approaches in radiation sensitization and protection.

    • Main Results:

    • Emerging knowledge in tumor, cellular, and molecular biology enhances understanding of clinical outcomes.
    • Hypoxic cell sensitizers show potential in improving radiation therapy efficacy.
    • Novel strategies for radiation sensitization and protection are under development.

    Conclusions:

    • Modulating tumor and normal tissue responses to ionizing radiation is a key area of research.
    • Integrating advances in biology is critical for improving radiation therapy outcomes.
    • Future directions include novel sensitization and protection strategies to enhance clinical results.