The neurochemistry of Parkinson's disease--comments on present and future developments

The neurochemistry of Parkinson's disease is currently undergoing considerable changes. From the analysis of diseased tissue and of lesion models, attention has turned to basic questions of neuronal development and neuronal death including the role played by trophic factors in the protection and regeneration of nervous tissue. Here some aspects are highlighted which emphasize molecular targets of possible causes and of future therapies, e.g., transmitter transporters and novel trophic effectors.