Neuroimmune mechanisms in Parkinson's disease

The potential role of immune mechanisms in the pathogenesis of Parkinson's disease is still a matter of controversy. Both peripheral and central immunological disturbances have been reported. It is possible that this altered function of the immune system is responsible for autodestruction of neurons in Parkinson's disease and other neurodegenerative disorders. In this case possible neuroprotective therapeutic strategies could be developed. However, further investigations are necessary to elucidate the conditions of normal or pathologic interaction between the brain and the immune system.