Brain lipofuscinolysis and ceroidolysis--to be or not to be

Lipofuscin pigment (LP) accumulations and ceroid pigment (CP) storages were demonstrated by multiple consensus studies. On the contrary, fewer researches, sometimes with opposite conclusions were made on brain LP and CP decrease, dissolution and elimination. Neuroactive agents (such as Meclofenoxate, Orotic acid, Antagonic-Stress, Piracetam, L-Deprenyl, Geriforte) generate LP and CP decrease and dissolution by cytoplasm rehydration, optimization of the brain cellular recycling system activities, by neuronal, glial and capillary LP lysis and CP lysis, by neurono-glio-endothelial transfer of highly processed LP and CP, with final capillary elimination. Therefore, these nootropic drugs may become therapeutical solutions in brain aging deceleration, in CP inductive circumstances and in age-associated diseases.