Repeated swim stress and peripheral-type benzodiazepine receptors
Related Experiment Video
Updated: Nov 4, 2026

Behavioral Approaches to Studying Innate Stress in Zebrafish
Published on: May 1, 2019
R Burgin1, R Weizman, M Gavish
1Department of Pharmacology, Technion-Israel Institute of Technology, Haifa.
Abstract:
The effect of daily forced swimming (15 min) of rats for 21 consecutive days on peripheral-type bentodiazepine receptors (PBR) was investigated. A significant reduction (-17%; p < 0.05) was observed in renal PBR in the stressed animals. A nonsignificant reduction of -18% was detected in adrenal PBR. The maximal binding capacity of [3H]PK 11195 was unaltered in the liver, heart, testis and thymus. It seems that the kidney is especially sensitive to repeated stress. The renal PBR reduction may be related to habituation to stress, and may reflect an adaptatory mechanism aimed at preventing long-term stress-induced overactivity of the renin-angiotensin system.
More Related Videos
05:17BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABAA Receptor Presentation in the Rodent Brain
Published on: May 26, 2023
07:16Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Related Concept Videos
Anxiolytic Drugs: Benzodiazepines and Buspirone
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
CNS Depressants: Barbiturates and Benzodiazepines
Desensitization and Tachyphylaxis
Several...
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...