Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How should zoster trials be conducted?

M J Wood1, H Balfour, K Beutner

  • 1Department of Infection and Tropical Medicine, Birmingham Heartlands Hospital, UK.

The Journal of Antimicrobial Chemotherapy
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topology-inclusive aerodynamic shape optimisation using a cellular automata parameterisation.

Structural and multidisciplinary optimization : journal of the International Society for Structural and Multidisciplinary Optimization·2025
Same author

Interpopulation differences and temporal synchrony in rates of adult survival between two seabird colonies that differ in population size and distance to foraging grounds.

Ecology and evolution·2023
Same author

Optimizing the Application Timing and Dosage of Metarhizium brunneum (Hypocreales: Clavicipitaceae) as a Biological Control Agent of Aedes aegypti (Diptera: Culicidae) Larvae.

Journal of medical entomology·2022
Same author

Association of tramadol with risk of myocardial infarction among patients with osteoarthritis.

Osteoarthritis and cartilage·2019
Same author

Cost-Utility Analysis of Preventive Home Visits in Older Adults.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

[Appraisal of Educational Programmes and Qualifications of Health Occupations/Professions: A European Comparison - Main Results and Conclusions].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2015

Clinical trial design for herpes zoster should define outcomes and analysis plans. For immunocompetent adults over 50, trials should focus on pain cessation as the primary endpoint, using intent-to-treat analysis.

Area of Science:

  • Virology
  • Clinical Trials Methodology
  • Epidemiology

Background:

  • Herpes zoster (shingles) poses significant challenges in clinical trial design, particularly concerning pain management.
  • Previous trials lacked standardized outcome measures and analysis plans, hindering comparability and interpretation.

Purpose of the Study:

  • To establish consensus on best practices for designing clinical trials investigating herpes zoster therapies.
  • To define key outcome measures, patient populations, and statistical approaches for herpes zoster research.

Main Methods:

  • International expert consensus meeting in 1994.
  • Prospective agreement on definitions for outcome measures and data analysis plans.
  • Focus on patient selection criteria (immunocompetent, age >50, within 72h of rash onset) and primary endpoints.

Related Experiment Videos

Main Results:

  • Agreement on pain cessation (≥4 weeks) as the primary endpoint for immunocompetent individuals.
  • Recommendation to treat pain duration as a continuous variable for statistical analysis.
  • Post-herpetic neuralgia incidence and quality of life as secondary endpoints.

Conclusions:

  • Standardized trial design elements are crucial for evaluating antiviral therapies in herpes zoster.
  • Intent-to-treat (ITT) analysis is recommended for primary endpoint evaluation.
  • Subgroup analyses should support, not replace, ITT findings.