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Related Experiment Videos

Ascorbic acid and atherosclerotic cardiovascular disease

S M Lynch1, J M Gaziano, B Frei

  • 1Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts 02118-2394, USA.

Sub-Cellular Biochemistry
|January 1, 1996
PubMed
Summary

Vitamin C (ascorbic acid) shows promise in preventing atherosclerosis and cardiovascular disease (CVD) based on animal studies and potential mechanisms. However, human evidence is inconclusive, necessitating further large-scale trials to confirm its benefits.

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Area of Science:

  • Cardiovascular Science
  • Nutritional Biochemistry

Background:

  • Atherosclerosis is a significant clinical manifestation of cardiovascular disease (CVD).
  • Vitamin C (ascorbic acid) plays a role in various metabolic processes.
  • Current understanding of vitamin C's role in atherosclerosis prevention is evolving.

Purpose of the Study:

  • To review the scientific knowledge on vitamin C's role in preventing atherosclerosis.
  • To evaluate evidence from animal, epidemiological, and clinical studies.
  • To explore potential mechanisms of action for vitamin C in CVD prevention.

Main Methods:

  • Review of animal studies (guinea pigs, rabbits) on vitamin C and atherosclerosis.
  • Analysis of epidemiological data linking vitamin C intake to CVD events.

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  • Examination of studies on vitamin C's effects on CVD risk factors (cholesterol, blood pressure).
  • Discussion of proposed biochemical mechanisms of vitamin C's action.

    • Main Results:

    • Animal studies suggest vitamin C can slow experimental atherosclerosis, but models have limitations.
    • Epidemiological studies show conflicting results regarding vitamin C intake and CVD incidence.
    • Vitamin C may moderately reduce total cholesterol, increase HDL, and lower blood pressure.
    • In vitro studies indicate vitamin C inhibits LDL oxidation.

    Conclusions:

    • Animal data is promising but requires primate studies for stronger conclusions.
    • Human evidence for vitamin C in CVD prevention is inconclusive.
    • Further large-scale, placebo-controlled trials are needed to confirm vitamin C's role.
    • Potential mechanisms include antioxidant effects, cholesterol metabolism, and arterial wall integrity.