Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

bcl-2: antidote for cell death

Y Tsujimoto1

  • 1Osaka University Medical School, Dept. of Medical Genetics, Japan.

Progress in Molecular and Subcellular Biology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

The BCL-2 proto-oncogene promotes cell survival by inhibiting apoptosis, a key step in cancer development. Understanding the BCL-2 family is crucial for deciphering the molecular basis of cell death.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ADC Level is Related to DWI Reversal in Patients Undergoing Mechanical Thrombectomy: A Retrospective Cohort Study.

AJNR. American journal of neuroradiology·2022
Same author

Evolution of the Magnetic Excitations in NaOsO_{3} through its Metal-Insulator Transition.

Physical review letters·2018
Same author

Production of feline leukemia inhibitory factor with biological activity in Escherichia coli.

Theriogenology·2016
Same author

Enhanced spin-phonon-electronic coupling in a 5d oxide.

Nature communications·2015
Same author

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Cell death and differentiation·2014
Same author

New members of layered oxychloride perovskites with square planar coordination: Sr2MO2Cl2 (M = Mn, Ni) and Ba2PdO2Cl2.

Chemical communications (Cambridge, England)·2014

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Death Research

Background:

  • The BCL-2 proto-oncogene, identified in human B-cell follicular lymphomas, enhances cell survival by interfering with apoptosis.
  • This discovery highlighted the role of inhibiting cell death in tumorigenesis.
  • Several cancer genes modulate the apoptotic process, supporting this notion.

Purpose of the Study:

  • To review current information on the BCL-2 gene and its family members.
  • To explore the role of BCL-2 in apoptosis and cancer.
  • To understand the molecular basis of apoptotic cell death through BCL-2 family analysis.

Main Methods:

  • Literature review of BCL-2 gene and family members.
  • Analysis of BCL-2's function in apoptosis.

Related Experiment Videos

  • Examination of BCL-2's role in tumorigenesis.

    • Main Results:

    • BCL-2 exerts a death-sparing activity against various apoptotic stimuli.
    • BCL-2 appears to function at a critical convergence point of apoptotic signals.
    • The BCL-2 family includes genes with similar or opposing functions to BCL-2.

    Conclusions:

    • Detailed analysis of BCL-2 family members is essential for understanding the molecular basis of apoptotic cell death.
    • Inhibition of apoptosis is a critical step in cancer development.
    • Further research into the BCL-2 family may yield insights into novel cancer therapies.