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Microbiological N-deoxygenation and C-oxygenation of pioglitazone-N-oxide in a single fermentation
R A Johnson1, V P Marshall, G P Li
1Research Laboratories, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
The Journal of Antibiotics
|August 1, 1996
Abstract:
Oxygenation of pioglitazone-N-oxide by a microorganism isolated from soil was accompanied by N-deoxygenation to produce the pioglitazone metabolites 5-[4-[2-[5-(1-hydroxyethyl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedio ne and 5-[4-[2-(5-acetyl-2-pyridyl)ethoxy]benzyl]2,4-thiazolidinedione. The oxygenating/deoxygenating organism has been characterized as Streptomyces hygroscopicus strain 02179 (UC 11099). The culture has been deposited with Agricultural Research Service, USDA, with accession number NRRL 18975.