YM-24074, a new peptide antibiotic. II. Structural elucidation
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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
T Sato1, Y Takebayashi, T Tokunaga
1Analytical Science Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Shizuoka Prefecture, Japan.
The Journal of Antibiotics
|August 1, 1996
Abstract:
YM-24074 (formerly called YL-01869P) is a new antibiotic and type I collagenase inhibitor. The structure of this compound was elucidated by spectroscopic analysis and confirmed by acid degradation to be N-(1"-acetyl-3"-methylbutyl)-2- [2'-[(N-hydroxycarbamoyl)methyl]heptanoyl]-hexahydropyrid azine-3-carboxamide. The stereochemistry of two of three chiral centers was determined by degradation products to be 3S, 2'R.

