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HLA-B27 subtypes in Japanese with seronegative spondyloarthropathies and healthy controls
A Yamaguchi1, A Ogawa, N Tsuchiya
1Department of Internal Medicine and Physical Therapy, Faculty of Medicine University of Tokyo, Japan.
Objective:
To determine HLA-B27 subtype frequencies in Japanese patients with seronegative spondyloarthropathies (SpA) and healthy controls.
Methods:
We determined HLA-B27 subtypes of 20 Japanese patients with ankylosing spondylitis and one with Reiter's syndrome, and 11 healthy Japanese individuals using a polymerase chain reaction sequence specific oligonucleotide hybridization method specifically designed for the discrimination of B*2701-09.
Results:
14 of 21 (67%) patients and 9 of 11 (82%) controls were typed as B*2704. The remainder were B*2705.
Conclusion:
HLA-B*2704 and B*2705 are present in the Japanese population, the former being the predominant subtype of HLA-B27. Both subtypes are associated with SpA.
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