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Related Experiment Videos

The steroid-eluting electrode: a 10-year experience

H G Mond1, K B Stokes

  • 1Department of Cardiology, Royal Melbourne Hospital, Victoria, Australia.

Pacing and Clinical Electrophysiology : PACE
|July 1, 1996
PubMed
Summary

Steroid-eluting electrodes maintain low stimulation thresholds for at least 10 years. Analysis of explanted leads indicates significant steroid remains even after 20 years, ensuring long-term efficacy.

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Area of Science:

  • Biomedical Engineering
  • Cardiology
  • Materials Science

Background:

  • Steroid-eluting electrodes are known to reduce stimulation thresholds.
  • The long-term duration of this effect remains a critical clinical question.

Purpose of the Study:

  • To determine the long-term efficacy of steroid-eluting electrodes in maintaining reduced stimulation thresholds.
  • To quantify the amount of remaining steroid in explanted leads over time.

Main Methods:

  • A 10-year prospective follow-up of a double-blind human study comparing steroid-eluting and non-eluting ventricular leads.
  • Analysis of remaining steroid content in 25 explanted leads (18 canine, 7 human) with implant times ranging from 1-350 weeks.

Main Results:

  • Steroid-eluting leads maintained consistently low stimulation thresholds over 10 years, unlike non-eluting leads.
  • Analysis of explanted leads suggests approximately 20% steroid remains at 10 years and 18% at 20 years.
  • Low steroid quantities are sufficient for the stimulation threshold-lowering effect.

Conclusions:

  • Steroid-eluting electrodes provide a clinically significant reduction in stimulation thresholds for at least 10 years.
  • Sufficient steroid is likely present for continued efficacy up to 20 years post-implantation.

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