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Updated: Jul 24, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Phase II trial of edatrexate in patients with metastatic colorectal cancer
G H Clamon1, C E Riggs, R Dreicer
1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, 52242, USA.
Abstract:
Edatrexate is an analog of methotrexate which in vitro demonstrated activity against human colon cancer xenografts grown in nude mice. In a phase II trial, 12 patients with metastatic colorectal cancer and no prior chemotherapy were treated with Edatrexate 80 mg/m2/week for an initial period of 8 weeks. No objective responses were observed. Edatrexate is inactive against colon cancer at the dose and schedule used in this trial.
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