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Co-existent eosinophilic gastroenteritis and hypothalamic-pituitary dysfunction

M R Haeney, R J Wilson

    Postgraduate Medical Journal
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    A 42-year-old man with eosinophilic gastroenteritis experienced diarrhea, blood loss, and malabsorption. Pituitary replacement therapy alone led to complete recovery, suggesting a novel link between endocrine dysfunction and this gastrointestinal condition.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Internal Medicine

    Background:

    • Eosinophilic gastroenteritis is a rare condition characterized by eosinophilic infiltration of the gastrointestinal tract.
    • Gastrointestinal symptoms can include diarrhea, abdominal pain, and malabsorption.
    • Endocrine disorders are not typically associated with eosinophilic gastroenteritis.

    Observation:

    • A 42-year-old male presented with symptoms of eosinophilic gastroenteritis, including diarrhea, fecal blood loss, protein-losing enteropathy, and malabsorption of fat, xylose, and vitamin B12.
    • The patient also exhibited co-existent hypopituitarism, diabetes insipidus, and hypothalamic dysfunction.
    • These endocrine abnormalities were diagnosed concurrently with the gastrointestinal symptoms.

    Findings:

    Related Experiment Videos

  • The patient's gastrointestinal and endocrine symptoms resolved completely following pituitary replacement therapy.
  • This case demonstrates a previously undescribed association between hypopituitarism and eosinophilic gastroenteritis.
  • The findings suggest a potential link between pituitary function and the pathogenesis or manifestation of eosinophilic gastroenteritis.

    • Implications:

    • This case highlights the importance of considering endocrine evaluation in patients with unexplained eosinophilic gastroenteritis.
    • Pituitary replacement therapy may be a crucial component in managing patients with co-existent eosinophilic gastroenteritis and hypopituitarism.
    • Further research is warranted to elucidate the underlying mechanisms connecting endocrine dysfunction and eosinophilic gastroenteritis.