Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Meiotic recombination hotspots

M Lichten1, A S Goldman

  • 1Division of Cancer Biology, Diagnosis and Centers, National Cancer Institute, Bethesda, Maryland 20892-4255, USA.

Annual Review of Genetics
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrochemical and chemical routes to hydride loss from an iridium dihydride.

Dalton transactions (Cambridge, England : 2003)·2016
Same author

The nun who wouldn't be: representations of female desire in two performance genres of "Si Fan.".

Late imperial China = Ch'ing shih wen t'i·2008
Same author

Concentrations of IL-10 in preterm human milk and in milk from mothers of infants with necrotizing enterocolitis.

Acta paediatrica (Oslo, Norway : 1992)·2004
Same author

Genesis of progressive T-cell deficiency owing to a single missense mutation in the common gamma chain gene.

Scandinavian journal of immunology·2002
Same author

Blood gammadelta T cells and gammadelta TCR V gene specificities in a single missense mutation (L-->Q271) in the common gamma chain gene.

Scandinavian journal of immunology·2002
Same author

The immunological system in human milk: the past--a pathway to the future.

Advances in nutritional research·2002
Same journal

Genomic Imprinting: Common Threads Uniting Diverse Biological Systems.

Annual review of genetics·2026
Same journal

Properties and Prospects of B Chromosomes.

Annual review of genetics·2026
Same journal

Lessons From Yeast: Mechanisms of Telomere Length Regulation.

Annual review of genetics·2026
Same journal

Mechanisms and Evolutionary Advantages of Unlimited Reproductive Lifespans in Naked Mole-Rat Queens.

Annual review of genetics·2026
Same journal

Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria.

Annual review of genetics·2025
Same journal

Context Specificity of MAP3K DLK Signaling in the Nervous System: Insights from Genetics and Genomics.

Annual review of genetics·2025
See all related articles

Meiotic recombination hotspots, regions of increased genetic exchange, show significant variation across eukaryotic genomes. This review focuses on hotspots in yeast and other organisms, highlighting current knowledge.

Area of Science:

  • Genetics
  • Molecular Biology
  • Genomics

Background:

  • Meiotic recombination is crucial for genetic diversity and proper chromosome segregation.
  • Recombination frequencies vary significantly across eukaryotic genomes, with specific regions exhibiting higher exchange rates.
  • These high-frequency regions are known as meiotic recombination hotspots.

Purpose of the Study:

  • To review the current understanding of meiotic recombination hotspots.
  • To focus on hotspots in Saccharomyces cerevisiae, a well-studied model organism.
  • To survey knowledge of hotspots in diverse species including other fungi, maize, nematodes, mice, and humans.

Main Methods:

  • Literature review of existing studies on meiotic recombination hotspots.
  • Comparative analysis of hotspot characteristics across different species.

Related Experiment Videos

  • Synthesis of current data on the distribution and properties of recombination hotspots.

    • Main Results:

    • Meiotic recombination hotspots are well-defined loci with elevated exchange frequencies.
    • Saccharomyces cerevisiae serves as a primary model for hotspot research, revealing key features.
    • Hotspots exhibit varying characteristics and distributions in other studied organisms.

    Conclusions:

    • Recombination hotspots are a conserved phenomenon across eukaryotes, though their specific features vary.
    • Further research is needed to fully elucidate the mechanisms and functional significance of hotspots in different species.
    • Understanding hotspots is critical for fields ranging from evolutionary genetics to human disease research.