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Loperamide poisoning in the dog
C Hugnet1, J L Cadore, F Buronfosse
1Centre National d'Informations Toxicologiques Veterinaires, ENVL, Marcy l'Etoile, France.
Veterinary and Human Toxicology
|February 1, 1996
Summary
Collie dogs appear susceptible to loperamide poisoning, often showing neurologic signs like ataxia. Naloxone effectively reversed these symptoms without lasting effects in a study of 40 cases.
Area of Science:
- Veterinary Toxicology
- Canine Pharmacology
Background:
- Loperamide, an opioid-receptor agonist used for diarrhea, can cause toxicity in dogs.
- Veterinary toxicology data is crucial for understanding drug-induced adverse events in animals.
Observation:
- A retrospective analysis of 40 canine loperamide poisoning cases was performed.
- Collie dogs exhibited a potential breed-specific susceptibility to loperamide toxicity.
- Significant clinical findings included neurologic disturbances such as ataxia and prostration.
Findings:
- Treatment with naloxone, an opioid antagonist, rapidly reversed the observed neurologic signs.
- No long-term adverse effects or sequelae were noted following naloxone administration.
Implications:
- This study highlights the importance of breed awareness in loperamide poisoning cases.
- Naloxone is a potentially effective antidote for managing loperamide toxicity in dogs.
- Further research into the pharmacokinetics and pharmacodynamics of loperamide in Collies is warranted.