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New peptide and protein drugs
1Department of Clinical Pharmacy and Toxicology, Leiden University Hospital, The Netherlands.
Pharmacy World & Science : PWS
|June 1, 1996
Summary
Peptide and protein drugs, including monoclonal antibodies and hormones, offer new therapeutic options. Pharmacists can optimize their use, but ethical considerations arise with expanded indications due to biotechnology advancements.
Area of Science:
- Pharmacology and Biotechnology
- Drug Development
- Therapeutic Modalities
Background:
- Peptide and protein drugs represent a growing class of therapeutics.
- Biotechnology has enabled the production of diverse protein and peptide-based medicines.
- Innovation is also occurring in vaccine development using these agents.
Purpose of the Study:
- To review recent developments, current status, and future perspectives of peptide and protein drugs.
- To highlight the pharmacotherapeutic implications of these advanced medicines.
- To discuss the role of pharmacists in optimizing drug application and addressing ethical concerns.
Main Methods:
- Literature review and synthesis of current knowledge on peptide and protein therapeutics.
- Analysis of pharmacotherapeutic applications and biotechnological production methods.
- Discussion of clinical and ethical considerations for expanded use.
Main Results:
- Peptide and protein drugs encompass a wide range, including recombinant hormones, cytokines, growth factors, and monoclonal antibodies.
- New pharmacotherapeutic approaches are emerging due to increased usage and experience.
- Recombinant technology has overcome previous supply limitations for many physiological substances.
Conclusions:
- Optimal application schemes for peptide and protein drugs require further refinement, with a key role for clinical pharmacists.
- The success of recombinant technology raises ethical questions regarding unlimited application and indication expansion.
- Continued research and collaboration are essential for the safe and effective use of these vital medicines.