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Related Experiment Videos

Risperidone-induced neuroleptic malignant syndrome

R Sharma1, B Trappler, Y K Ng

  • 1Arnold and Marie Schwartz College of Pharmacy, Long Island University, NY, USA.

The Annals of Pharmacotherapy
|July 1, 1996
PubMed
Summary

Neuroleptic Malignant Syndrome (NMS) can occur with risperidone, an atypical antipsychotic. Clinicians should be aware of this serious adverse event when prescribing risperidone.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Medicine

Background:

  • Neuroleptic Malignant Syndrome (NMS) is a rare but life-threatening condition.
  • Atypical antipsychotics, such as risperidone, are increasingly used in psychiatric practice.
  • Understanding the risk factors and presentation of NMS associated with atypical antipsychotics is crucial.

Observation:

  • A case report details an adolescent male who developed NMS.
  • The patient experienced NMS after initiating risperidone therapy.
  • Symptoms included fever, muscle rigidity, altered mental status, and autonomic dysfunction.

Findings:

  • Risperidone, an atypical antipsychotic, was implicated in inducing NMS.
  • The patient recovered after discontinuation of risperidone and supportive care.
  • Literature review indicates a potential association between risperidone and NMS.

Implications:

  • Healthcare providers should exercise caution when prescribing risperidone.
  • Awareness of NMS symptoms is vital for early diagnosis and management.
  • Further research may be needed to fully elucidate the risk of NMS with risperidone.

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