Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Corticosteroids and ulcers: is there an association?

P G Pecora¹, B Kaplan

¹Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh Medical Center, PA, USA.

The Annals of Pharmacotherapy

|July 1, 1996

Summary

Corticosteroids likely cause ulcers, especially with NSAIDs, high doses, or long-term use. Prophylaxis is generally unnecessary, but prudent for high-risk patients pending more research on prevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mueller matrix of dense polystyrene latex sphere suspensions: measurements and Monte Carlo simulation.

Applied optics·2008

Same author

Use of low dose tacrolimus, mycophenolate mofetil and maintenance IL-2 receptor blockade in an islet transplant recipient.

Clinical transplantation·2008

Same author

Phase-modulated mueller ellipsometry characterization of scattering by latex sphere suspensions.

Applied optics·2008

Same author

Comparison of visual function and ocular hemodynamics between pre- and post-menopausal women.

European journal of ophthalmology·2008

Same author

Prophylaxis versus preemptive protocols for CMV: do they impact graft survival?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2008

Same author

Toenail abnormalities and onychomycosis in chronic venous insufficiency of the legs: should we treat?

Journal of the European Academy of Dermatology and Venereology : JEADV·2008

Area of Science:

Gastroenterology
Pharmacology

Background:

Corticosteroids are widely used medications.
Gastrointestinal (GI) ulcers are a potential adverse effect.

Purpose of the Study:

To review the association between corticosteroid use and peptic ulcer disease (PUD).
To identify risk factors for corticosteroid-induced ulcers.
To evaluate the role of prophylactic therapy.

Main Methods:

Literature review of studies examining corticosteroid use and GI ulcers.

Main Results:

A small but probable association exists between corticosteroids and ulcers.
High-risk patients often have concurrent NSAID use, high corticosteroid dosage (>1000 mg prednisone equivalent), prolonged duration (>30 days), or a history of PUD.
The efficacy of prophylactic therapy is not well-established, with limited evidence from specific populations like liver transplant recipients.

Conclusions:

Most current prophylaxis for corticosteroid-induced ulcers may be unnecessary.
Prophylaxis is recommended for high-risk patients until further evidence is available.
Further prospective research is needed to clarify the association and optimal prophylactic strategies.

Related Experiment Videos