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Nonsteroidal antiinflammatory drug use and cognitive function in the elderly: inconclusive results from a
A Fourrier1, L Letenneur, B Bégaud
1Arme-Pharmacovigilance, Centre de Pharmacovigilance, Hôpital Pellegrin, Bordeaux, France.
Abstract:
As part of the cohort Paquid, we studied the relationship between the use of NSAID, incidence of dementia, and evolution of cognitive functions. Dementia was diagnosed by DSM-III criteria and cognitive functions was assessed through the Mini-Mental Status Examination (MMSE). During 2 years of follow-up, the incidence rate of dementia was 3.84% among 53 NSAID users as compared with 3.77% in 1199 nonusers (OR, 0.98; 95% CI, 0.23-4.16). Using a cutoff of -3 points for the MMSE score and taking into account age and educational status in a logistic regression model, NSAID use was related to an unfavourable variation of the MMSE score (OR, 2.84; 95% CI, 0.99-8.1).