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Aldosterone cord levels in preterm newborn infants
R S Procianoy1, E A de Oliveira-Filho
1Department of Paediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Acta Paediatrica (Oslo, Norway : 1992)
|May 1, 1996
Summary
Umbilical cord aldosterone levels were measured in premature infants. Higher levels were found in newborns with greater gestational age and birthweight, indicating these factors influence aldosterone in neonates.
Area of Science:
- Neonatal Physiology
- Endocrinology
Background:
- Aldosterone plays a crucial role in fluid and electrolyte balance.
- Understanding aldosterone levels in premature infants is important for neonatal care.
Purpose of the Study:
- To measure umbilical cord aldosterone concentrations in premature newborns.
- To investigate the influence of perinatal factors on these levels.
Main Methods:
- Umbilical cord blood samples were collected from 64 premature infants.
- Serum aldosterone concentrations were measured.
- Correlation with gestational age and birthweight was analyzed.
Main Results:
- The median umbilical cord aldosterone level was 74.5 ng/dL (range: 22-280 ng/dL).
- Gestational age and birthweight significantly influenced aldosterone levels.
- Infants >34 weeks gestation and >2000g birthweight had higher aldosterone levels.
Conclusions:
- Gestational age and birthweight are significant determinants of umbilical cord aldosterone levels in premature infants.
- These findings contribute to understanding neonatal endocrine adaptation.