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Antiphospholipid antibodies in children
S Kontiainen1, A Miettinen, I Seppälä
1Department of Paediatrics and Medical Microbiology, Aurora Hospital, Helsinki, Finland.
Acta Paediatrica (Oslo, Norway : 1992)
|May 1, 1996
Summary
Antiphospholipid antibodies (aPL) were more prevalent and at higher levels in children than adults. This suggests current normal values for aPL may need adjustment for pediatric populations.
Area of Science:
- Immunology
- Pediatrics
Background:
- Antiphospholipid antibodies (aPL) are associated with thrombosis and pregnancy complications.
- Establishing reference ranges for aPL in pediatric populations is crucial for accurate diagnosis.
Purpose of the Study:
- To determine the prevalence and levels of IgG anti-cardiolipin antibodies (GPL) in children compared to adults.
- To assess the need for adjusted normal values of aPL in children.
Main Methods:
- Enzyme immunoassay was used to detect IgG anti-cardiolipin antibodies (GPL).
- Sera from 173 children and 100 adults were analyzed.
Main Results:
- A significantly higher percentage of children (82%) tested positive for aPL compared to adults (27%) (p < 0.001).
- Higher levels of GPL were detected more frequently in children.
- Approximately 5% of children had GPL levels >= 45 GPL U/mL, while 5% of adults had levels >= 25 GPL U/mL.
Conclusions:
- The prevalence and levels of antiphospholipid antibodies (aPL) are significantly higher in children than adults.
- Current normal values for aPL may not be appropriate for pediatric populations.
- Further studies are warranted to establish age-specific reference ranges for aPL in children.