Related Experiment Video
Updated: Jul 22, 2026

06:37
Staphylococcus aureus Growth using Human Hemoglobin as an Iron Source
Published on: February 7, 2013
Carriage of Staphylococcus aureus in the elderly
R M Parnaby1, G O'Dwyer, H A Monsey
1Central Middlesex PHL and NHS Trust, London, UK.
The Journal of Hospital Infection
|July 1, 1996
Summary
One in three elderly inpatients carry Staphylococcus aureus, with a 2.9% incidence rate for MRSA. Screening nostrils and skin breaks is most cost-effective for detecting carriage.
Area of Science:
- Infectious Diseases
- Epidemiology
- Geriatric Medicine
Background:
- Staphylococcus aureus, including methicillin-resistant strains (MRSA), is a significant healthcare-associated pathogen.
- Understanding carriage rates and risk factors in elderly inpatients is crucial for infection control.
Purpose of the Study:
- To estimate the point prevalence and incidence of Staphylococcus aureus carriage in elderly inpatients.
- To determine the relationship between carriage, body site, and previous healthcare exposures.
- To identify cost-effective screening strategies.
Main Methods:
- A point prevalence study of 55 patients and a two-month incidence study of 136 patients were conducted.
- Data collected included S. aureus carriage status, body site of isolation, and patient history.
- Statistical analysis was used to determine associations and incidence rates.
Main Results:
- One in three elderly inpatients carried S. aureus; 1 in 20 were infected.
- The incidence rate for MRSA was 2.9%.
- Nostril carriage was significantly associated with overall carriage, while skin breaks were significant in the prevalence survey. No endemic strain was identified.
Conclusions:
- Nostril and skin break screening are cost-effective methods for identifying S. aureus carriage in this population.
- Targeted screening can improve infection control measures for elderly inpatients.
- Further research into endemic strains may be warranted.
More Related Videos
Related Concept Videos
Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Pneumonia I: Introduction
Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

