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Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA)
D F Talkington1, B G Brown, J A Tharpe
1Division of Bacterial and Mycotic Diseases, Center for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Microbial Pathogenesis
|July 1, 1996
Abstract:
Pneumococcal surface adhesin A (PsaA) is a 37-kDa surface protein present on Streptococcus pneumoniae having significant homology with fimbrial adhesion proteins. Immunization of CBA/CaHNJ Xid mice with PsaA using either complete Freund's or TiterMax adjuvants significantly protected mice against heterologous intravenous challenge with type 3 pneumococcal strain WU2 at doses up to 45 times the LD50. The results indicate that PsaA warrants further evaluation as a vaccine candidate for human pneumococcal disease.