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[Bone marrow transplantation from an unrelated donor in patient with congenital heart diseases]
H Kumazaki1, R Hanada, A Kikuchi
1Saitama Children's Medical Center.
Insights
Unrelated donor bone marrow transplant (UBMT) is feasible for children with chronic myelogenous leukemia (CML) and congenital heart disease (CHD). This approach can be successful even with complex cardiac conditions, offering a life-saving option.
Area of Science:
- Hematology
- Pediatric Oncology
- Cardiology
Background:
- Chronic myelogenous leukemia (CML) in pediatric patients presents unique treatment challenges.
- Congenital heart disease (CHD) can complicate standard treatment protocols, including hematopoietic stem cell transplantation.
- Unrelated donor bone marrow transplantation (UBMT) is an option for patients lacking a matched sibling donor.
Abstract:
A 9-year-old with chronic myelogenous leukemia (CML) who received bone marrow transplantation from an unrelated donor (UBMT), is reported. He also suffered from congenital heart disease (CHD) consisting of corrected transposition of the great arteries and dextrocardia. The cardiac output was within normal limits. The conditioning regimen included busulfan, melphalan, ALG and TLI. Cyclophosphamide was not used because of it cardiotoxicity. The HLA-phenotype of the donor was identical with that of the patient. DNA typing showed was haplodentical DRB1. The patient is alive 18 months after the UBMT. This case showed that UBMT was possible in a CML patient with CHD, without congestive heart failure.