Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Orthostatic intolerance after spaceflight

J C Buckey1, L D Lane, B D Levine

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of carbon dioxide on physical and cognitive performance in a simulated spacesuit contingency scenario.

NPJ microgravity·2026
Same author

The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights.

Journal of neurology·2026
Same author

Acute effects of postural changes and lower body positive and negative pressure on the eye.

Frontiers in physiology·2022
Same author

Anaesthetists and aerospace medicine in a new era of human spaceflight.

Anaesthesia·2021
Same author

Patient preferences for stratified medicine in psoriasis: a discrete choice experiment.

The British journal of dermatology·2021
Same author

Detecting changes in distortion product otoacoustic emission maps using statistical parametric mapping and random field theory.

The Journal of the Acoustical Society of America·2020
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Orthostatic intolerance after spaceflight is common. Postflight, crew members showed similar reductions in stroke volume but finishers had a stronger vasoconstrictor response, indicating better cardiovascular adaptation.

Area of Science:

  • Cardiovascular physiology
  • Space medicine
  • Human physiology

Background:

  • Orthostatic intolerance is a frequent issue for astronauts post-spaceflight.
  • The precise physiological mechanisms underlying this condition remain incompletely understood.
  • Understanding these mechanisms is crucial for astronaut health and mission success.

Purpose of the Study:

  • To investigate the hemodynamic differences between astronauts who successfully completed a postflight orthostatic stress test and those who did not.
  • To elucidate the underlying cardiovascular adaptations contributing to orthostatic tolerance after space missions.

Main Methods:

  • Studied 14 astronauts before and after 9-14 day space shuttle missions.
  • Assessed hemodynamic responses during supine and standing positions using a 10-minute stand test.
Keywords:
NASA Discipline CardiopulmonaryNASA Discipline Number 00-00NASA Discipline Number 14-10NASA Discipline Number 93-10NASA Program FlightNASA Program NSCORTNASA Program Space Physiology and CountermeasuresNon-NASA Center

Related Experiment Videos

  • Measured stroke volume, heart rate, cardiac output, and total peripheral resistance.

    • Main Results:

    • 64% of astronauts experienced orthostatic intolerance postflight, unable to complete the stand test.
    • Postflight, both successful and unsuccessful groups exhibited similar reductions in stroke volume and increases in heart rate.
    • Astronauts who completed the stand test demonstrated a significantly greater postflight vasoconstrictor response (increased total peripheral resistance).

    Conclusions:

    • The primary postural decrease in stroke volume is not the differentiating factor in post-spaceflight orthostatic tolerance.
    • Heart rate and cardiac output responses during standing did not significantly differ between groups.
    • A robust vasoconstrictor response is a key compensatory mechanism for maintaining orthostatic tolerance after spaceflight.