Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central venous pressure in space

J C Buckey1, F A Gaffney, L D Lane

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of carbon dioxide on physical and cognitive performance in a simulated spacesuit contingency scenario.

NPJ microgravity·2026
Same author

The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights.

Journal of neurology·2026
Same author

Viz.ai Implementation of Stroke Augmented Intelligence and Communications Platform to Improve Indicators and Outcomes for a Comprehensive Stroke Center and Network.

AJNR. American journal of neuroradiology·2022
Same author

Acute effects of postural changes and lower body positive and negative pressure on the eye.

Frontiers in physiology·2022
Same author

Heart transplantation outcomes in cardiac sarcoidosis.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2021
Same author

Anaesthetists and aerospace medicine in a new era of human spaceflight.

Anaesthesia·2021
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Gravity significantly impacts cardiac filling pressure. Central venous pressure (CVP) monitoring revealed a decrease in microgravity, yet cardiac filling increased, altering the CVP-filling pressure relationship.

Area of Science:

  • Cardiovascular Physiology
  • Space Medicine
  • Fluid Dynamics

Background:

  • Gravity profoundly influences cardiovascular dynamics, particularly cardiac filling pressures and fluid distribution.
  • Microgravity abolishes hydrostatic gradients, causing a major central fluid shift.
  • Continuous monitoring of cardiac filling pressure, specifically central venous pressure (CVP), is crucial for understanding these dynamics.

Purpose of the Study:

  • To investigate the changes in central venous pressure (CVP) and cardiac filling during microgravity exposure.
  • To assess the relationship between CVP and left ventricular filling pressure in microgravity.

Main Methods:

  • Direct measurement of CVP using a 4-Fr catheter in three astronauts across two space shuttle missions (Spacelab Life Sciences-1 and -2).
Keywords:
NASA Discipline CardiopulmonaryNASA Discipline Number 00-00NASA Discipline Number 14-10NASA Program FlightNASA Program Space Physiology and CountermeasuresNon-NASA Center

Related Experiment Videos

  • Continuous CVP monitoring initiated 4 hours pre-flight and extended into microgravity.
  • Echocardiography was used to measure left ventricular end-diastolic dimensions.

    • Main Results:

    • Mean CVP decreased from 8.4 cmH2O (seated pre-flight) to 2.5 cmH2O after 10 minutes in microgravity.
    • Despite the drop in CVP, left ventricular end-diastolic dimension increased from 4.60 cm (supine pre-flight) to 4.97 cm within 48 hours in microgravity.
    • These findings indicate increased cardiac filling in microgravity despite a reduced CVP.

    Conclusions:

    • The relationship between central venous pressure (CVP) and transmural left ventricular filling pressure is altered in microgravity.
    • Cardiac filling appears to increase early in microgravity, contrary to what a simple CVP decrease might suggest.
    • Further research is needed to fully elucidate cardiovascular adaptations to microgravity.