Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Forced expirations and maximum expiratory flow-volume curves during sustained microgravity on SLS-1

A R Elliott1, G K Prisk, H J Guy

  • 1Department of Medicine, University of California, San Diego, La Jolla 92093-0931, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 1, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excess energy and photosynthesis: responses to seasonal water limitations in co-occurring woody encroachers of the semi-arid Southern Great Plains.

Photosynthetica·2024
Same author

Vaping causes an acute BMI-dependent change in pulmonary blood flow.

Physiological reports·2024
Same author

Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.

Journal of applied physiology (Bethesda, Md. : 1985)·2019
Same author

Spatial persistence of reduced specific ventilation following methacholine challenge in the healthy human lung.

Journal of applied physiology (Bethesda, Md. : 1985)·2018
Same author

Endotypes of difficult-to-control asthma in inner-city African American children.

PloS one·2017
Same author

Predawn disequilibrium between plant and soil water potentials in two cold-desert shrubs.

Oecologia·2017

Sustained microgravity temporarily reduced peak expiratory flow rate (PEFR) and other lung function measures. These effects largely recovered during spaceflight, suggesting adaptation to microgravity or altered mechanics.

Area of Science:

  • Space physiology
  • Respiratory mechanics
  • Pulmonary function testing

Background:

  • Gravity significantly impacts lung and chest wall mechanics.
  • The effects of sustained microgravity on forced expiratory maneuvers remain largely uncharacterized.

Purpose of the Study:

  • To investigate the impact of sustained microgravity on forced expiratory parameters.
  • To compare lung function in microgravity with preflight standing and supine postures.

Main Methods:

  • Four subjects performed forced expiratory maneuvers during 9 days of microgravity exposure on Spacelab Life Sciences-1.
  • Data were collected during preflight, in-flight, and postflight sessions in standing and supine postures.

Main Results:

Keywords:
NASA Discipline CardiopulmonaryNASA Discipline Number 00-00NASA Discipline Number 14-10NASA Program FlightNASA Program Space Physiology and CountermeasuresNon-NASA Center

Related Experiment Videos

  • Peak expiratory flow rate (PEFR) was significantly reduced in early microgravity but recovered by flight day 9.
  • Forced vital capacity and forced expired volume in 1 second showed transient reductions and later increases compared to preflight standing values.
  • Supine posture consistently reduced PEFR and other expiratory flows, particularly at lower lung volumes.

    • Conclusions:

    • Sustained microgravity causes transient alterations in forced expiratory mechanics, with some recovery observed during spaceflight.
    • The reduction in PEFR may be related to altered physical stabilization or transient respiratory muscle weakness in microgravity.
    • Supine posture significantly impacts expiratory flow dynamics, independent of microgravity effects.