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Central venous pressure in humans during microgravity

N Foldager1, T A Andersen, F B Jessen

  • 1Danish Aerospace Medical Centre of Research, Rigshospitalet, Copenhagen, Denmark.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 1, 1996
PubMed
Summary
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Central venous pressure (CVP) in humans does not increase in microgravity. Studies show CVP decreases during short parabolic flights and remains similar or lower than supine levels during longer space missions.

Area of Science:

  • Space physiology
  • Cardiovascular research

Background:

  • Understanding fluid shifts and cardiovascular adaptation is crucial for spaceflight.
  • Previous hypotheses suggested central venous pressure (CVP) increases in microgravity.

Purpose of the Study:

  • To test the hypothesis that CVP increases in microgravity compared to the ground-based supine position.
  • To investigate CVP changes during both short-term (parabolic flight) and longer-term (space mission) microgravity exposure.

Main Methods:

  • CVP was measured using an intravascular pressure transducer in healthy subjects.
  • Data collected during parabolic flights (20-second microgravity periods) and a 3-hour Spacelab D-2 mission.

Main Results:

  • During parabolic flights, CVP decreased from 6.5 mmHg to 5.0 mmHg in microgravity (P < 0.05).

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  • During the Spacelab D-2 mission, initial microgravity CVP was 6.2 mmHg, similar to pre-flight supine values.
  • Over 3 hours of weightlessness, CVP ranged from 2.0 to 6.2 mmHg.

    • Conclusions:

    • Central venous pressure in humans is not elevated during short or extended periods of microgravity.
    • CVP during microgravity is comparable to or lower than ground-based supine CVP.