Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glycosaminoglycans in autoimmunity

C Hansen1, E Otto, K Kuhlemann

  • 1Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany.

Clinical and Experimental Rheumatology
|May 1, 1996
PubMed
Summary

Glycosaminoglycans (GAGs) are implicated in autoimmune diseases like lupus and thyroid disease. Altered GAG levels, particularly chondroitin and dermatan sulfate, serve as markers for disease activity and severity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of self-trial without catheter pathway following elective urological surgery.

Annals of the Royal College of Surgeons of England·2026
Same author

The benefits and societal importance of pig welfare in slaughterhouses a narrative review.

Meat science·2025
Same author

The Magnetic Search Coil (MSC) on the TRACERS Mission.

Space science reviews·2025
Same author

Low latency optical-based mode tracking with machine learning deployed on FPGAs on a tokamak.

The Review of scientific instruments·2024
Same author

Tangential extreme ultraviolet and soft x-ray diagnostic system for time-resolved temperature measurement on the High Beta Tokamak-Extended Pulse.

The Review of scientific instruments·2023
Same author

Assistance dogs help reduce mental health symptoms among Australian Defence Force veterans and emergency services personnel: A pilot study.

Psychiatry research·2023

Area of Science:

  • Biochemistry
  • Immunology
  • Pathology

Background:

  • Alterations in glycosaminoglycans (GAGs) and proteoglycans are linked to autoimmune disease development.
  • Anti-DNA antibodies cross-reacting with GAGs like hyaluronic acid and heparan sulfate are found in systemic lupus erythematosus patients.
  • Elevated hyaluronic acid antibodies correlate with disease severity in autoimmune thyroid disease.

Purpose of the Study:

  • To analyze the structure and distribution of GAGs in autoimmune disease patients.
  • To develop a highly specific HPLC method for GAG analysis.
  • To establish GAGs as potential biomarkers for autoimmune disease activity.

Main Methods:

  • Development of a highly specific High-Performance Liquid Chromatography (HPLC) method.

Related Experiment Videos

  • Analysis of GAG composition and distribution in tissues and body fluids.
  • Quantification of urinary GAG excretion in patients with autoimmune thyroid disease and diabetes mellitus.

    • Main Results:

    • Increased urinary chondroitin sulphate and dermatan sulphate concentrations in autoimmune thyroid disease patients, correlated with disease activity.
    • Markedly higher renal GAG excretion in autoimmune diabetes mellitus patients, correlated with disease duration and complications.
    • Demonstrated fibroblast stimulation and increased collagen and GAG production in a chicken autoimmune model.

    Conclusions:

    • GAG polysaccharides play a significant role in the pathogenesis of autoimmune diseases.
    • Specific GAGs, like chondroitin and dermatan sulfate, can serve as activity markers for autoimmune diseases.
    • Further research into GAGs could lead to novel diagnostic and therapeutic strategies for autoimmune conditions.