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Lithium-induced Creutzfeldt-Jakob syndrome
B Casanova1, M de Entrambasaguas, C Perla
1Department of Neurology, Hospital Universitari La Fe, Valencia, Spain.
Clinical Neuropharmacology
|August 1, 1996
Summary
Lithium carbonate treatment can cause Creutzfeldt-Jakob like syndrome in elderly patients with bipolar disorder. Discontinuing lithium led to full recovery, suggesting neurotoxicity should be considered in differential diagnosis.
Area of Science:
- Neuroscience
- Psychiatry
- Toxicology
Background:
- Lithium carbonate is a common treatment for bipolar disorder.
- Creutzfeldt-Jakob disease (CJD) is a rare, fatal neurodegenerative disorder.
- Lithium-induced neurotoxicity can mimic CJD symptoms.