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Calciphylaxis in chronic renal failure
M N Budisavljevic1, D Cheek, D W Ploth
1Department of Medicine, Medical University of South Carolina, Charleston 29425-2220, USA.
Journal of the American Society of Nephrology : JASN
|July 1, 1996
Summary
Calciphylaxis, a severe complication in end-stage renal disease (ESRD), causes skin lesions due to microvascular calcification and thrombosis. Its unclear etiology and poor prognosis highlight the need for better understanding and treatment strategies.
Area of Science:
- Nephrology
- Dermatology
- Pathophysiology
Background:
- Calciphylaxis is a rare, life-threatening complication affecting ~1% of ESRD patients annually.
- Characterized by microvascular calcification and thrombosis, it leads to painful skin lesions, ulcers, and sepsis, predominantly on lower extremities.
- Despite common calcium/phosphate imbalances, the exact cause of calciphylaxis remains elusive.