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Reference values for serum selenium in various areas-evaluated according to the TRACY protocol

G Alfthan1, J Neve

  • 1National Public Health Institute, Department of Nutrition, Helsinki, Finland.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|June 1, 1996
PubMed
Summary

This study reviewed 291 papers on serum selenium levels, identifying 36 suitable for establishing reference values. Geographical area and sampling time significantly impact selenium concentrations in healthy adults.

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Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Human Physiology

Background:

  • Published reports on selenium concentrations in serum and plasma require critical evaluation.
  • The international TRACY project aimed to establish reliable reference values for selenium exposure assessment.
  • Pre-analytical and analytical factors influence serum selenium measurements.

Purpose of the Study:

  • To critically review published reports on serum and plasma selenium concentrations.
  • To identify key pre-analytical and analytical factors affecting selenium reference values.
  • To establish reliable reference values for evaluating selenium deficiency or excess.

Main Methods:

  • Systematic review of 291 papers published between 1983 and 1993.
  • Application of TRACY project expert group criteria for paper selection.

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  • Inclusion of data only from healthy adults to minimize age and health status variations.

    • Main Results:

    • 36 out of 291 reviewed papers met the TRACY project criteria.
    • Geographical area and time of sampling were identified as highly important pre-analytical factors.
    • Gender, occupation, diet, and medication use were also significant determinants of serum selenium levels.

    Conclusions:

    • A universal reference serum selenium value is not feasible due to geographical variations in intake.
    • Selected data allowed for documenting serum selenium levels across different geographical areas, primarily in Europe.
    • Consistent application of TRACY criteria will enhance the reliability and significance of future selenium research.