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Nephrotic syndrome in the elderly

J S Cameron1

  • 1Renal Unit, UMDS Guy's Campus, London, England.

Seminars in Nephrology
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Nephrotic syndrome in older adults is common but often misdiagnosed. Early diagnosis and treatment are crucial, as age alone should not prevent intervention, despite higher risks.

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Area of Science:

  • Nephrology
  • Geriatrics

Background:

  • Nephrotic syndrome in patients over 60 is as common as in younger adults.
  • It is frequently misdiagnosed as heart failure, particularly when elevated jugular venous pressure is present.
  • Clinical presentation is similar to younger patients, but acute renal insufficiency is more common.

Purpose of the Study:

  • To review the characteristics, causes, and outcomes of nephrotic syndrome in elderly patients.
  • To emphasize the importance of diagnosis and treatment in this population.

Main Methods:

  • Review of 164 nephrotic patients aged over 60.
  • Meta-analysis of over 1,000 patients from existing literature.

Main Results:

  • Membranous nephropathy (35%), minimal change disease (16%), and primary amyloidosis (12%) are common causes in the elderly.

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  • Survival rates are lower and treatment side effects are more pronounced compared to younger patients.
  • Renal biopsy is essential for diagnosis in elderly patients.

    • Conclusions:

    • Nephrotic syndrome in the elderly requires prompt diagnosis and treatment, irrespective of age.
    • Age should not be a barrier to renal biopsy or therapeutic interventions.
    • Screening for neoplasia should include chest radiography and fecal occult blood testing.