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4-Chloro-7-(iodoacetyl)amino-3-methoxy-isocoumarin
J E Kerrigan1, J C Powers, D VanDerveer
1School of Chemistry and Biochemistry, Georgia Institute, Atlanta 30332-0400, USA.
Acta Crystallographica. Section C, Crystal Structure Communications
|February 15, 1996
Abstract:
The crystal structure of the iodo analog of 7-(bromoacetyl)amino-4-chloro-3-methoxyisocoumarin, an inhibitor of human neutrophil elastase (HNE), C12H9ClINO4, has been determined. The isocoumarin ring system is highly planar, with the carbonyl group of the amide function being coplanar with the isocoumarin ring.