Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary function in acromegaly

C C Evans, L J Hipkin, G M Murray

    Thorax
    |June 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Acromegaly patients, particularly males, may experience enlarged lung volumes and upper airway narrowing. These respiratory issues, linked to disease duration, are more critical than lung function changes in acromegaly.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical Efficacy of Biosimilar Switch of Adalimumab for Management of Uveitis.

    Ocular immunology and inflammation·2023
    Same author

    Severe hepatotoxicity as a rare side effect of anakinra in a patient with systemic JIA.

    Rheumatology (Oxford, England)·2021
    Same author

    Altered regional brain T2 relaxation times in individuals with chronic orofacial neuropathic pain.

    NeuroImage. Clinical·2018
    Same author

    Disruption of default mode network dynamics in acute and chronic pain states.

    NeuroImage. Clinical·2017
    Same author

    The medial pterygoid muscle: a stabiliser of horizontal jaw movement.

    Journal of oral rehabilitation·2017
    Same author

    Effect of experimental anterior temporalis muscle pain on jaw movements.

    Journal of oral rehabilitation·2016
    Same journal

    Mediastinal amyloidosis mimicking advanced lung cancer.

    Thorax·2026
    Same journal

    Comparative performance of endobronchial ultrasound-guided sampling techniques in patients with mediastinal lesions: a network meta-analysis.

    Thorax·2026
    Same journal

    Vitamin A and D impact on lung function: differential or common effects across the lifespan?

    Thorax·2026
    Same journal

    The impact of vitamins A and D on lung function and regulatory epigenetics in adult and childhood asthma.

    Thorax·2026
    Same journal

    Radiological factors associated with the recurrence of <i>Mycobacterium avium complex</i> pulmonary disease: a multicentre retrospective cohort study.

    Thorax·2026
    Same journal

    Daughter vesicles in primary diaphragmatic hydatid cyst.

    Thorax·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Pulmonology
    • Respiratory Medicine

    Background:

    • Acromegaly, a condition caused by excess growth hormone, can affect multiple organ systems.
    • Respiratory complications in acromegaly are not fully understood, impacting patient outcomes.

    Purpose of the Study:

    • To investigate pulmonary function and upper airway dimensions in acromegaly patients without other cardiorespiratory diseases.
    • To determine the prevalence of respiratory abnormalities in acromegaly and their potential causes.

    Main Methods:

    • Physiological and radiographic assessment of lung volumes in 20 acromegaly patients (12 female, 8 male).
    • Evaluation of expiratory-inspiratory flow rate ratio to assess upper airway narrowing.
    • Laryngoscopy performed on three patients to confirm laryngeal changes.

    Related Experiment Videos

    Main Results:

    • Enlarged lung volumes observed in 50% of males, but not in females, accounting for thoracic kyphosis.
    • Increased expiratory-inspiratory flow rate ratio suggesting upper airway narrowing in 6 patients (4 males).
    • Confirmed acromegaly of the larynx in 3 subjects.

    Conclusions:

    • Upper airway obstruction, including laryngeal changes, is a significant respiratory risk in acromegaly, potentially more so than enlarged lung volumes.
    • Respiratory findings were not correlated with fasting growth hormone levels but showed a trend with longer disease duration.