Related Experiment Videos
Cyproheptadine treatment in neuroleptic-induced akathisia
D Weiss1, D Aizenberg, H Hermesh
1Gehah Psychiatric Hospital, Petah Tiqva, Israel.
Abstract
Background:
Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic-induced akathisia.
Method:
In an open clinical trial 17 neuroleptic-treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D.
Results:
All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued.
Conclusions:
Cyproheptadine may be useful in neuroleptic-induced akathisia.