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Changes in adhesion molecule levels in sepsis

H Nakae1, S Endo, K Inada

  • 1Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.

Research Communications in Molecular Pathology and Pharmacology
|March 1, 1996
PubMed
Summary
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Soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in sepsis and correlates with endotoxins and inflammatory cytokines. This suggests endotoxins and cytokines influence sICAM-1 levels, but not the quantity of leukocyte adhesion molecules.

Area of Science:

  • Immunology
  • Critical Care Medicine
  • Molecular Biology

Background:

  • Sepsis involves complex inflammatory responses.
  • Adhesive molecules play a role in immune cell trafficking during inflammation.
  • The relationship between adhesion molecules and cytokines in sepsis requires further clarification.

Purpose of the Study:

  • To investigate the relationship between soluble intercellular adhesion molecule-1 (sICAM-1) and leukocyte adhesion molecules (CD11a, CD11b, CD18) in sepsis.
  • To determine the correlation between these molecules and endotoxin/cytokine levels in sepsis patients.

Main Methods:

  • Measured sICAM-1, CD11a, CD11b, CD18, endotoxin, and cytokine levels in sepsis and trauma patients.
  • Analyzed correlations between measured parameters using statistical methods.

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Main Results:

  • Significantly higher sICAM-1 levels were observed in the sepsis group compared to the trauma group.
  • No significant differences in CD11a, CD11b, or CD18 levels were found between groups.
  • sICAM-1 levels correlated positively with endotoxin, TNF-alpha, and IL-8 levels.

Conclusions:

  • sICAM-1 production in sepsis is induced by endotoxins and cytokines.
  • Endotoxins and cytokines appear to influence the qualitative aspects of LFA-1 and Mac-1, rather than their quantitative expression.